NEW STEP BY STEP MAP FOR ISORHAMNETIN-3-O-GLUCOSIDE

TAK-243 preferentially bound to UBA1 more than the related E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 diminished levels of ubiquitylated proteins, amplified markers of proteotoxic strain and DNA hurt tension. In vivo, TAK-243 minimized leukemic load and targeted leukemic stem cells without the need of proof

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